Learn About Knox County’s Largest Employers
We’re Home to a Diversified Mix of Industries
We’re Home to a Diversified Mix of IndustriesKnox County, Illinois is home to a long list of companies. Many of our largest employers have thrived in Knox County for more than a century. Here are some of our major employers whose names you probably recognize.
Rail Classification Yard
1,031 Employees
BNSF Railway is one of North America’s leading freight transportation companies, with a rail network of 32,500 route miles in 28 states and two Canadian provinces. BNSF is one of the top transporters of the products and materials that help feed, clothe, supply and power communities throughout America and the world.
Regional Medical Center
880 Employees (2026)
OSF improves lives by providing quality health care that is affordable, leads to the best patient experience and improves the overall health of the community. They are committed to providing care in new and innovative ways that allow people to stay in their hometown – removing the barriers for care, and to bringing more services to those with fewer resources.
Distribution and E-commerce Fulfillment
555 Employees (2026)
Founded in Galesburg in 1911, Blick Art Materials (DickBlick.com) is the largest and oldest provider of art supplies in the United States with more than 65 retail stores nationwide. The company’s extensive product selection, competitive prices, and superior customer service make Blick the best choice for anyone requiring quality art materials for work or pleasure.
Healthcare
167 Employees (2026)
Bridgeway is a not-for-profit human services organization dedicated to improving the lives of individuals with disabilities in west central Illinois and southeast Iowa. Bridgeway staff work to provide creative solutions and job opportunities, as well as services such as data entry, janitorial services, and metal fabrication.
Education
448 Employees (2026)
Knox College is a nationally ranked liberal arts college in Galesburg, Illinois, devoted to providing a personalized education that prepares students to be engaged, innovative, and productive global citizens, ready to lead lives of purpose and to work in fields that don’t exist yet. Current enrollment is around 1,300, with students from 48 states and 51 countries.
Major Employers
Contact: Ken Springer ken@knoxpartnership.com